Novel Treatments for Rheumatoid Arthritis

Disease Modifying Anti-Rheumatic Drugs (DMARDs) are the only drugs demonstrated to modify the course of the rheumatoid arthritis and improve radiologic findings. There are 2 types of DMARDs: biologic and syntethic small molecules. Among the biologic DMARDs are tumor necrosis factor alpha (TNF-a) inhibitors; T-cell costimulatory blocking agents and B-cell depleting agents

HLA: matching and donor selection

MHC genes and molecules

The imune system MHC class I and II molecules and the genes that encode their synthesis are showed in this video, including an illustration of the MHC gene locus and an illustration of the MHC molecular structure.The distribution of the MHC molecules on the cells is also illustrated.